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The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with (65).In this cohort, obese individuals exhibited higher circulating levels of IL-17, supporting the concept that IL-17driven inflammation may be particularly prominent in this subgroup and may contribute to increased disease activity and reduced therapeutic responsiveness (66)
Mechanistically, SM significantly enhanced -endorphin expression in the spinal dorsal horn and primary microglia [72]
Fleenor, D., Arumugam, R
miR-93 was first reported to directly regulate GLUT4 expression in adipocytes
Studies on OC cell lines (SKOV3 and A2780) and xenograft mouse models showed that VB suppresses OC cell proliferation, migration, and promotes apoptosis
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